New Study shows #Famotidine reduce Cytokine Storm in #COVID virus symptoms

A phase two clinical trial has shown the efficacy of #Famotidine in alleviating corona disease symptoms by stimulating vagus nerve, which suppresses cytokine storm – a severe immune reaction where the body releases too many inflammatory proteins into the body.

The vagus nerve turns off inflammation in the body, a process called inflammatory relfex. If the inflammatory reflex or vagus nerve is impaired, the result is an unchecked abundance of inflammation, which can contribute to autoimmune diseases, including Rheumatoid arthritis and Crohn’s disease.

When Famotidine was administered to mice, it significantly reduced serum and spleen levels of cytokines TNF and Interleukin 6 (IL-6) and improved survival, which means that the inflammatory reflex is famotidine’s mechanism of action.

Researchers noted that future studies are needed to replicate the findings of using famotidine to combat COVID-19 and that this new research was conducted in animal models, not humans. Just as direct electrical stimulation of the vagus nerve has shown to improve a variety of diseases, famotidine too – a well-tolerated and generic drug – may one day offer additional methods of activating the inflammatory reflex to reduce inflammation.